Biodegradable silk fibroin based materials for orthopedics

Aim of this project is biocompatible material development in reproducible and medical quality and defined degradation time in simulated body conditions. Main aim is development of two different types of materials for orthopedic aplication - nanofibrous membrane (till 03/2020) and lyophilized 3D scaffold (till 06/2020), in case of need their combination. Both types of material preparation will be realized primarily in laboratory, subsequently in semiindustrial conditions. Part of the material development is also basic in vitro degradability and cytotoxicity testing using cell culture lines. Optimalized materials will be subsequently sent to preclinical and clinical trials to certificated comapnies.