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Development of new types of fully biocompatible conductive organosilane fibrous scaffolds intended for soft and neural tissues regeneration

Registration number:23-04868S

Realization period:01.01. 2023 – 31.12. 2025

Leader at TUL:doc. Mgr. Veronika Máková, Ph.D.

There is a great need of novel materials for replacements and “intelligent” wound dressings within the skin and neuronal tissue engineering. We have succeeded in developing purely hybrid organosilane conductive nanofibrous materials, without the use of additives or surfactants that can be toxic. So far, no one has succeeded in developing such an intelligent biomaterial that would meet the set aims (biocompatibility, biodegradability, conductivity). At the same time, scaffolds made of our unique fibres, thanks to their fibrous form, have the potential not only to support the growth and proliferation of nerve cells but also to provide a suitable environment for signal transmission or endogenous electric field, which also contributes to healing chronic wounds. Developed materials will be tested with stem cells, and tissue-specific cells, including nerve cell precursors. Based on preliminary results, our organosilane scaffolds, thanks to their unique hybrid properties, show more than promising potential, especially in the field of regeneration of specific tissues such as nerve tissue.

General partners

Škoda AUTO
Česká Zbrojovka
FM Motol
UJV Group