COMbined Physico-chemical Experimental Therapy to Improve prognosis against Triple negative breast by Immune activation and laser ablation OptimizatioN.

The lack of specific cellular targets makes triple-negative breast cancer (TNBC) hardly treatable and often leads to the worst prognosis. TNBC can moderately respond to chemotherapy, but the systemic administration of drugs often leads to toxicity have many patients must stop the cure. Safe and reliable alternatives are needed. The ablative laser photothermal (PTT) is theoretically very promising, but its clinical translation is still limited due to the potential detrimental effects on the surrounding parenchyma. In the last years the PI is optimizing, in collaboration with the Politecnico of Milano, a new laser able to both improve the anatomical resolution and reduce the intensity of stimulation by the use of gold NP antennas directly injected into the mass of TNBC bearing mice.